Необязательно создавать целый проект:

app.py

from django.conf import settings
from django.conf.urls import url
from django.http import HttpResponse

settings.configure(
    ROOT_URLCONF=__name__,
)


def index(request):
    return HttpResponse("Hello, world !")

urlpatterns = [
    url(r'^$', index)
]


if __name__ == '__main__':
    
    from django.core.servers.basehttp import run
    from django.core.wsgi import get_wsgi_application

    app = get_wsgi_application()

    run('127.0.0.1', 8888, app)